Transcriptome-wide maps of mouse interneurons after chronic stress

Using Sst and parvalbumin subtype-specific fluorescence activated cell sorting (FACS) and RNA sequencing we identify distinct transcriptome profiles for these interneuron subtypes in the medial PFC. Chronic stress causes significant dysregulation of several key pathways, including sex specific differences in the SST interneuron profiles. Examination of sex-specific transcriptomic profiles in two interneuron subtypes