Proteins that are highly divergent in East Asian and non-Asian strains of <i>H. pylori.</i>

aAssignment of genes into functional groups is based on classifications of H. pylori 26695 genes reported in the JCVI Comprehensive Microbial Resource database, based on analysis of three H. pylori genomes (26695, J99 and HPAG1). bGene numbers in H. pylori reference strain 26695 are shown. cAnnotations are based on data reported in the JCVI Comprehensive Microbial Resource database or data reported in Genbank at the time when this study was undertaken. dThree proteins initially classified as “hypothetical” were subsequently found to exhibit similarity to proteins of known function. These include HP0861 [corresponding to heavy metal (copper tolerance) in Shewanella and integral membrane protein in Campylobacter], HP0635 (corresponding to hydrogenase E in Campylobacter) and HP1321 (corresponding to an ATPase in Wolinella and other species). Conserved domain analysis indicates that HP0861 belongs to the Dsb superfamily, HP0384 belongs to the SPOR superfamily, and HP1321 belongs to both the P-loop-containing nucleoside triphosphosphate hydrolase superfamily and the helix-turn-helix superfamily. eNot applicable. HomB is absent from strain 26695.