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Cofilactin rod formation mediates inflammation-induced neurite degeneration.

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NIAID Data Ecosystem2026-05-01 收录
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Uruk et al. demonstrate that the brain inflammatory response causes neurite (axon and dendrite) degeneration by a mechanism involving NOX2-induced cofilactin rod (CAR) formation. Neurites are more vulnerable to Inflammation-induced injury than neuronal cell bodies, and neurite loss in the absence of neuronal cell body loss is associated with functional impairment.

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2024-03-04
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