pFREE cured strain WGS

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CRISPR脱靶效应

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数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP111391 数据链接链接失效反馈

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资源简介：

Whole genomes of cured strains were sequenced to assess potential off target effects of the pFREE CRISPR based plasmid curing platform.

创建时间：

2017-07-13

Crosstalk between CRISPR-Cas9 and the human transcriptome

CRISPR脱靶效应

转录组互作分析

CRISPR-Cas9 expression independent of its cognate synthetic guide RNA (gRNA) causes widespread genomic DNA damage in human cells. To investigate whether Cas9 can interact with endogenous human RNA tra

NIAID Data Ecosystem30

A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

CRISPR脱靶效应

基因组编辑特异性

Clustered regularly interspaced short palindromic repeat (CRISPR) RNA-guided nucleases have gathered considerable excitement as a tool for genome engineering. However, questions remain about the speci

NIAID Data Ecosystem30

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors [P2A-EGFP control]. Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors [P2A-EGFP control]

CRISPR脱靶效应

"RNA研究"

Base Editing has been touted the most intelligent and precise application of the CRISPR platform so far, merging the simplicity of RNA-guided nucleases with deaminases that allow for the programmable

NIAID Data Ecosystem20

Supplemental Material for Fernandez et al., 2019

基因编辑DNA修复分析

CRISPR脱靶效应

This Supplemental Data set includes raw data utilized for the TIDE (Tracking across Indels by DEcomposition) method. Supplemental Table S1 provides raw data for the proportion of NHEJ with end process

NIAID Data Ecosystem30

on- and off-target analysis

基因组编辑评估

CRISPR脱靶效应

Comprehensively on- and off-target analysis using targeted deep sequencing

NIAID Data Ecosystem20