HIV-1 reverse transcriptase in complex with DNA and EFdA-triphosphate, a translocation-defective RT inhibitor

NIAID Data Ecosystem2026-05-02 收录

HIV药物开发

逆转录酶抑制

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HIV-1 reverse transcriptase in complex with DNA and EFdA-triphosphate, a translocation-defective RT inhibitor

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2024-10-23

Development of Covariate Adjustment Methods to Improve Efficiency of Randomized Clinical Trials for human immunodeficiency virus infected Patients

HIV药物开发

临床试验方法学

Drug development requires significant time and financial resources. Despite the remarkable success in treating patients infected with the human immunodeficiency virus (HIV), which causes serious infec

DataCite Commons2026-03-06 更新70

Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3‑ d ]pyrimidine Derivatives as Human Immunodeficiency Virus‑1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles

HIV药物开发

非核苷类逆转录酶抑制剂

In the current landscape of antiretroviral options, there remains an urgent need for novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) with improved resistance profiles and safety propert

NIAID Data Ecosystem30

Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer

结直肠癌靶向治疗

逆转录酶抑制

Colorectal cancer aberrant repeat RNA expression can be therapeutically targeted with reverse transcriptase inhibitors. The experiments performed were on colorectal cancer (CRC) cell lines in differen

NIAID Data Ecosystem30

Molecular dynamics of rubromycin derivatives bound to WT and mutant reverse transcriptase

分子动力学模拟

HIV药物开发

Data labeled as mutB refer to the E138K/M184I mutant. Data labeled as mutant refer to the K103N/Y181C mutant. files containing "_0_" in their names refer to gamma-rubromycin-bound reverse transcriptas

Figshare2016-01-18 更新50

RNA-Seq of AZT and 3TC treated mouse neuronal cells

神经细胞转录组学

逆转录酶抑制

The study aims at determining the transcriptomics response of cultured primary mouse neurons after exposing them to azidothymidine (AZT) and lamivudine (3TC) drugs, used to inhibit the reverse transcr

NIAID Data Ecosystem30

HIV-1 reverse transcriptase in complex with DNA and EFdA-triphosphate, a translocation-defective RT inhibitor

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