Crystal Structure of small molecule vinylsulfonamide 15 covalently bound to K-Ras G12C
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Crystal Structure of small molecule vinylsulfonamide 15 covalently bound to K-Ras G12C Descriptor: GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[N-(5,7-dichloro-2,1,3-benzothiadiazol-4-yl)glycyl]piperidin-4-yl}ethanesulfonamide Authors: Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. Deposit date: 2013-08-04 Release date: 2013-11-27 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.491 Å) Cite: K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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2013-08-04
