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A mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

ChEBI2014-04-24 更新2026-07-21 收录

白血病靶向治疗

未折叠蛋白反应研究

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-53685 数据链接链接失效反馈

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A mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

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2014-04-24

儿科肝胆疾病

未折叠蛋白反应研究

Background/Aims: Cholestatic liver diseases (CLD) are the leading indication for pediatric liver transplantation. Increased intrahepatic bile acid concentrations cause endoplasmic reticulum (ER) stres

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Endoplasmic Reticulum Stress

内质网应激信号

未折叠蛋白反应研究

The Endoplasmic Reticulum Stress network depicts the causal mechanisms that regulate endoplasmic reticulum stress including the unfolded protein response and the pathways downstream of the three key s

NIAID Data Ecosystem50

Role of ERN2/IRE1b in mediating unfolded protein response to ER stress

内质网应激

未折叠蛋白反应研究

The purpose of this study was to understand how expression of the ER stress sensor ERN2/IRE1b affects the unfolded protein response to ER stress Overall design: Comparative gene expression analysis of

NIAID Data Ecosystem20

Relevance of Unfolded Protein Response to Spaceflight-Induced Transcriptional Reprogramming in Arabidopsis. Relevance of Unfolded Protein Response to Spaceflight-Induced Transcriptional Reprogramming in Arabidopsis

植物应激反应

未折叠蛋白反应研究

Plants are primary producers of food and oxygen on Earth and will likewise be indispensable to the establishment of large-scale sustainable ecosystems and human survival in space. To contribute to the

NIAID Data Ecosystem50

Viral priming of innate antiviral signaling by the unfolded protein response

病毒先天免疫调控

未折叠蛋白反应研究

The cellular response to a pathogen is critical in determining the outcome of the infection and, as a consequence, viruses deploy a variety of strategies to subdue the antiviral signalling in order to

NIAID Data Ecosystem20

A mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

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