Identification of a novel enhancer of CEBPE essential for granulocytic differentiation

NIAID Data Ecosystem2026-03-13 收录

粒细胞分化

增强子功能分析

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE122676 数据链接链接失效反馈

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资源简介：

RNA-Seq of Control, dCas9-KRAB-EV, dCas9-KRAB-sg2 and dCas9-KRAB-sg5 Differential expression between cell types (EV and sg2/sg5 knock down)

创建时间：

2022-05-21

HAX1 controls mitochondrial proteostasis

线粒体蛋白质

粒细胞分化

The relevance of mitochondrial proteostasis for the differentiation and function of hematopoietic and immune cells is unknown. Dissecting the HCLS1-associated protein X-1 (HAX1) –related protein netwo

NIAID Data Ecosystem50

Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks [CrispR_FOXA1]. Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks [CrispR_FOXA1]

膀胱癌表观遗传学

增强子功能分析

RNA-seq Series of Bladder carcinoma cell lines RT112 and SD48 mutated for FOXA1 by CrispR. Overall design: RT112 and SD48 CRispR mutated for FOXA1 and controls.

NIAID Data Ecosystem30

The transcriptional equilibration between androgen receptor and MYC signatures during prostate cancer transition centralizes on a distal developmental super-enhancer circuitry. The transcriptional equilibration between androgen receptor and MYC signatures during prostate cancer transition centralizes on a distal developmental super-enhancer circuitry

癌症转录调控

增强子功能分析

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem20

Single cell transcriptomics resolves basophil differentiation trajectory and identifies pre-basophils

单细胞转录组学

粒细胞分化

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem40

A neutropenia-associated transcription factor mutation differentially impacts target genes in the cell-states traversed during granulocyte specification and commitment [CITE-seq-GMP-WT]

粒细胞分化

单细胞转录组学

Advances in genetics and sequencing have lead to a deluge of disease-associated and disease-causing genetic alterations. Resolving causality between genetics and disease requires generating accurate m

NIAID Data Ecosystem30

Identification of a novel enhancer of CEBPE essential for granulocytic differentiation

资源简介：

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