Rh(III)-Catalyzed Traceless Coupling of Quinoline <i>N</i>‑Oxides with Internal Diarylalkynes
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Quinoline N-oxides were found to undergo Cp*Rh(III)-catalyzed coupling with internal diarylalkynes to provide 8-functionalized quinolines through a cascade process that involves remote C–H bond activation, alkyne insertion, and intramolecular oxygen atom transfer. In this reaction, the N-oxide plays a dual role, acting as a traceless directing group as well as a source of oxygen atom, as confirmed by an 18O-labeling experiment.
创建时间：
2016-02-16
