Brain Delivery and Biodistribution of the Kv1.3 Channel Blocker, HsTX1[R14A], a Potential Therapeutic for Neuroinflammatory Diseases

There are many steps involved in the molecular cascade that causes the clinical symptoms of Alzheimer’s disease, and identifying which step to try to block is complex. Recently, a critical step in the process was identified, which is hyper-activation of the immune cells (microglia) in our brain. My research efforts include delivery of a novel peptide toxin (HsTX1) derived from a scorpion to the brain in order to specifically block this step and stop the disease.