Dehydrative Transformation of Spirooxindoles to Pyrido[2,3‑b]indoles via POCl3
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资源简介：
A two-step one-pot efficient synthesis of pyrido[2,3-b]indoles via reaction between isatin, α-amino acid, and dipolarophile has been developed. The initial 1,3-dipolar cycloaddition between the reactants that is performed in the presence of either CuI or methanol results in spirooxindoles that undergo POCl3-mediated intramolecular dehydrative transformation to afford the title compounds.
创建时间：
2019-03-20
