Inflammation-associated alterations to the intestinal microbiota reduce colonization resistance against non-typhoidal Salmonella during concurrent malaria parasite infection

Childhood malaria is a risk factor for disseminated infections with non-typhoidalSalmonella (NTS) serotypes in sub-Saharan Africa. It is not known whether malaria affects colonization resistance of the host to NTS. To address this question, this study utilized a murine model of concurrent infection withPlasmodium yoelii nigeriensis (P. yoelii) and NTS.