Estimated Percentages of Adults with current D(m) and Pure MDD in NESARC excluded from Typical Clinical Trials of Treatments for DSM-IV MDD by Traditional Eligibility Criteria.

aDerived from Zimmerman et al. [29] (method described in the paper).bIncludes panic disorder, agoraphobia, social anxiety disorder, specific phobia, and generalized anxiety disorder.Percentages are weighted values.Abbreviations: MDD = Major Depressive Disorder, D(m) = MDD plus Subthreshold Hypomania, D(BP2) = Bipolar 2 depressive disorder, HAM-D = Hamilton Rating Scale for Depression, NESARC = National Epidemiological Survey on Alcohol and Related Conditions, NA = information not available in NESARC.Models 1, 2, 3 and 4 indicates that subthreshold hypomania was defined as having respectively at least 1, 2, 3, or 4 lifetime concomitant hypomanic probes screening criterion A or B for hypomania.