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CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation

NIAID Data Ecosystem2026-05-02 收录

免疫代谢

CRISPRi功能基因组学

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE231502 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-10-27

奶牛乳腺炎防控

免疫代谢

Mastitis, a major dairy industry challenge, is often caused by Staphylococcus aureus (S. aureus). Previous research linked gut microbiota disruption—induced by vancomycin in mice—to reduced microbial

NIAID Data Ecosystem70

Aldosterone induces trained immunity: the role of fatty acid synthesis.

免疫代谢

血管炎症机制

Supranormal levels of aldosterone are associated with increased cardiovascular risk in humans, and with accelerated atherosclerosis in animal models. Atherosclerosis is a low-grade inflammatory disord

NIAID Data Ecosystem50

JCI:Lactate supports Treg function and immune balance viaMGAT1 effects on N-glycosylation in the mitochondria

免疫代谢

Treg细胞功能

Current research reports that lactate affects Treg metabolism, although the precise mechanism has only been partiallyelucidated. In this study, we presented evidence demonstrating that elevated lactat

Figshare2024-09-17 更新40

Developing & Optimizing Acute Myeloid Leukemia Specific Therapeutic Antibodies [CRISPR Screen]. Developing & Optimizing Acute Myeloid Leukemia Specific Therapeutic Antibodies [CRISPR Screen]

抗体药物研发

CRISPRi功能基因组学

Following nearly five decades with few approved therapies for acute myeloid leukemia (AML), the last three years have brought stellar progress with the U.S. Food and Drug Administration approving a nu

NIAID Data Ecosystem50

The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses

免疫代谢

细胞信号调控

Metabolic fitness of T cells is crucial for immune responses against infections and tumorigenesis. Both the T cell receptor (TCR) signal and environmental cues contribute to the induction of T cell me

NIAID Data Ecosystem50

CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation

资源简介：

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