Cicatricial Alopecia pathogenesis: Uniqueness or similarities between lymphocytic subtypes Lichen planopilaris (LPP) and Central centrifugal cicatricial alopecia (CCCA)

Microarray analyses of LPP and CCCA was undertaken to decipher differential pathophysiological pathways leading to disease initiation and progression Scarring alopecia consists of a collection of disorders characterized by destruction of hair follicles, replacement with fibrous scar tissue, and irreversible hair loss. Alopecia affects men and women worldwide and can be a significant source of psychological stress and depression for affected individuals. The purpose of this study was to explore Gene expression profiles in scalp tissue samples from normal control subjects (n=1(comprising 10 pooled samples)) and in matched samples obtained from affected (n=3) and unaffected (n=3) areas of the scalp in patients with Central centrifugal cicatricial alopecia (CCCA) as well with matched samples obtained from affected (n=7) and unaffected (n=7) areas of the scalp in patients with Lichen planopilaris (LPP) .