CRISPR/Cas9 system has innate off-target recognition and cleavage activity, which is also inherent to base editors. Most of current decrease off-target strategies are either too complicated or have re
We examined the off-targets of new base editing tools at RNA level Overall design: cells transfected with different base editing tools or GFP were cultured for 48 hours and total RNA was purified for
CRISPR/Cas9 system has innate off-target recognition and cleavage activity, which is also inherent to base editors. Most of current decrease off-target strategies are either too complicated or have re
