Epidemiological and experimental evidence indicates that antibiotic exposure is related to metabolic malfunctions, such as obesity and non-alcoholic fatty liver disease (NAFLD). Liver impairment and h

NIAID Data Ecosystem40

Gene expression profile of neonate mouse epidermis stem cell after transplacental exposure to Arsenic in drinking water. Mus musculus

砷毒性机制研究

干细胞基因表达

Background: The metalloid Arsenic is potentially toxic, genotoxic, and carcinogenic to humans. The metalloid poisining in drinking-water is a widespread problem affecting a large population globally.

NIAID Data Ecosystem30

?Arsenic toxicity is regulated by queuine availability and oxidation- induced reprogramming of the human tRNA epitranscriptome

砷毒性机制研究

tRNA表观转录组修饰

?Cells respond to environmental stress by regulating gene expression at the level of both transcription and translation. The ~50 modified ribonucleotides of the human epitranscriptome contribute to th

NIAID Data Ecosystem40

Ablation of liver Fxr results in an increased colonic mucus barrier in mice. Ablation of liver Fxr results in an increased colonic mucus barrier in mice

肠-肝轴机制

Fxr受体功能研究

The inter-organ cross talk between liver and intestine has been focus of intense research. Key in this cross-talk are bile acids, which are secreted from the liver into the intestine and, via the ente

NIAID Data Ecosystem40