Comparing Gene Expression Profiling of ATO sensitive and Resistant cell lines. Comparing Gene Expression Profiling of ATO sensitive and Resistant cell lines

To further characerize the arsenic trioxide (ATO) resistance in acutepromyelocytic leukemia, we had made NB4 cell line (arsenic sensitive) to be resistant to arsenic by exposing them to increasing concentration till they are resistant to it and we named it NB4-EV-AsR1. We have also used another cell line (UF1) which is by default resistant to arsenic. Comparing the GEP will give us novel pathways that can contirbute to arseic trioxide. Overall design: Organism : Homo sapiens, Agilent's Human Gene Expression 8x60k Array (AMADID: 039494) Contributor: Genotypic Technology Private Limited, Bangalore