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Stereoselective Synthesis of Highly Functionalized 5- and 6‑Membered Aminocyclitols Starting with a Readily Available 2‑Azetidinone

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NIAID Data Ecosystem2026-03-11 收录
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Stereoselective transformations of 4-vinyl-2-azetidinone derivative 4 into a variety of highly functionalized 6- and 5-membered carbocyclic compounds 7 and 9 were carried out using sequences involving sequential C1–N bond cleavage and Ru-catalyzed ring-closing metathesis. The derived carbocycles were further transformed into polyhydroxylated 6- and 5-membered aminocyclitols.

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2019-03-26
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