Crystal Structure of human Brachyury G177D variant in complex with CF-5-86

Crystal Structure of human Brachyury G177D variant in complex with CF-5-86 Descriptor: N-(4-((2-fluorophenyl)(hydroxy)methyl)phenyl)acetamide, PHOSPHATE ION, T-box transcription factor T Authors: Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O. Deposit date: 2022-04-12 Release date: 2022-06-22 Last modified: 2025-02-26 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy. Nat Commun, 16, 2025