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FkbI for Biosynthesis of Methoxymalonyl Extender Unit of Fk520 Polyketide Immunosuppresant

NIAID Data Ecosystem2026-05-01 收录

聚酮类生物合成

抑制剂开发

数据链接：

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资源简介：

FkbI for Biosynthesis of Methoxymalonyl Extender Unit of Fk520 Polyketide Immunosuppresant

应用场景：

创建时间：

2024-02-14

抑制剂开发

肿瘤免疫治疗

Small molecular PD-1 inhibitors are lacking in current immuno-oncology clinic. PD-1/PD-L1 antibody inhibitors currently approved for clinical usage block interaction between PD-L1 and PD-1 to enhance

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Synthetic Studies toward A-74528

聚酮类生物合成

有机合成方法

A potentially biomimetic approach toward the complex polyketide A-74528 is described. It is based on highly substituted biaryl compounds, synthesized using advanced cross-coupling and condensation met

NIAID Data Ecosystem40

Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase

抑制剂开发

糖原储存疾病治疗

The overaccumulation of glycogen appears as a hallmark in various glycogen storage diseases (GSDs), including Pompe, Cori, Andersen, and Lafora disease. Accumulating evidence suggests that suppression

NIAID Data Ecosystem30

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase

癌症靶向治疗

抑制剂开发

Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic target for cancer. B13 is an effective an

NIAID Data Ecosystem40

Stereoselective Total Synthesis of Aminoiminohexitols via Carbamate Annulation

立体选择性合成

抑制剂开发

New methodology for the preparation of a variety of aminoiminohextitols is described. Key in the synthesis is the application of a diastereoselective Strecker reaction and the extension of our carbama

NIAID Data Ecosystem30

FkbI for Biosynthesis of Methoxymalonyl Extender Unit of Fk520 Polyketide Immunosuppresant

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