SARS-CoV-2 Papain-like Protease (PLpro) in complex with Fragment 41

SARS-CoV-2 Papain-like Protease (PLpro) in complex with Fragment 41 Descriptor: N'-[3-(2-{[(7M)-8-methyl-7-(2-methylpyridin-4-yl)-3,4-dihydrospiro[[1]benzopyran-2,4'-piperidin]-1'-yl]methyl}pyridin-3-yl)propanoyl]-4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-4-oxobutanehydrazide, Papain-like protease nsp3, ZINC ION Authors: Taylor, A.J. Deposit date: 2025-10-31 Release date: 2026-02-18 Last modified: 2026-02-25 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Discovery of Spiro[chromane-2,4'-piperidine] Derivatives as Irreversible Inhibitors of SARS-CoV-2 Papain-like Protease. J.Med.Chem., 69, 2026