首页/数据集/Changes in glycogen metabolism machinery are associated with brain aging. Proteomic and immunofluorescent evidence for and against the astrocyte-to-neuron lactate shuttle

Changes in glycogen metabolism machinery are associated with brain aging. Proteomic and immunofluorescent evidence for and against the astrocyte-to-neuron lactate shuttle

NIAID Data Ecosystem2026-03-10 收录

衰老相关代谢

神经细胞代谢

数据链接：

https://www.omicsdi.org/dataset/pride/PXD006815 数据链接链接失效反馈

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资源简介：

Analysis of proteome changes during mouse brain aging

应用场景：

创建时间：

2018-03-05

神经细胞代谢

有氧酵解

Different distribution of PKM2 drives neurons to use aerobic glycolysis in somata to prevent oxidative damage and OXPHOS in terminals to meet high energy demands.

DataCite Commons2025-05-01 更新40

Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver.

核纤层机制

衰老相关代谢

Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and age-dependent metabolic changes, but the mechanism is unknown. He

NIAID Data Ecosystem30

Gene expression profiling in the liver of 3-month old mice with a mutant Wrn protein treated with vitamin C compared to the liver of 3-month old untreated mice with a mutant Wrn protein.. Mus musculus

维生素C干预研究

衰老相关代谢

Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcr

NIAID Data Ecosystem30

Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters

神经细胞代谢

老年减肥干预

Central insulin is involved in the regulation of hedonic feeding. Insulin resistance in overweight has recently been shown to reduce the inhibitory function of insulin in the human brain, but how this

NIAID Data Ecosystem40

代谢组学

衰老相关代谢

Detailed knowledge of tissue-specific metabolic profiles of the lung is vital for elucidating the molecular pathological signature of lung aging and exploring potential metabolic targets to improve ag

Figshare2024-06-15 更新30

Changes in glycogen metabolism machinery are associated with brain aging. Proteomic and immunofluorescent evidence for and against the astrocyte-to-neuron lactate shuttle

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