Validation of Mitra ?VAMS as a bloodcollection technique for trace elementsanalysis using ICP-MS/MS: supplementary data

Background: Clinical dosage of toxic and essential elements in blood is well established and the collectionmethod is still by venipuncture. This method has drawbacks and is not suited for everyone. Volumetricabsorptive microsampling (VAMS) has been shown to have advantages over venipuncture. Materials& methods: Using inductively coupled plasma tandem mass spectrometry, a method for quantifyingelements in whole blood sampled on VAMS was developed/validated.Method’s performance was assessedby comparison with whole blood results. Results: Validation and performance assessment tests tend toshow that most of the targeted elements provides accurate and reproducible results comparing to amethod of reference. Conclusion: Overall, VAMS presents good preliminary results to eventually becomean alternative to venipuncture for blood sampling for some trace elements analysis purposes.