SARS-CoV-2 enhances lysosomal exocytosis efficiency and deacidifies lysosomes to facilitate viral release
收藏Mendeley Data2026-04-09 收录
官方服务:
资源简介:
The sequences of plasmids in the paper
应用场景:
相关数据集
CLN7是调节溶酶体功能的细胞器氯离子通道
神经元蜡样脂褐质沉积症(NCL)是一种常染色体隐性溶酶体贮积症。晚发型NCL(vLINCL)的一种变异形式是由溶酶体膜蛋白CLN7的突变引起的,其功能一直不明。在这里,我们发现CLN7是一种新型溶酶体内氯离子通道。过表达CLN7可增加溶酶体内氯离子电流,并通过Ca2+/钙调蛋白依赖性方式增大溶酶体。人源CLN7及其酵母同源物表现出氯离子通道的特征,并对氯离子通道阻断剂敏感。此外,CLN7还能调节溶
中国科学院中国科学技术大学科学数据中心310
Additional file 3 of Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Additional file 3: Supplementary Table S2. Proteomics and statistical results for Lyso-APEX, Lyso-IP, and Lyso-BAR. Source data for Figs. 1, 2 and 3.
DataCite Commons2024-08-16 更新140
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis
How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in C9orf72 is the most common cause of familial amyotrophic lateral sclero
DataCite Commons2024-02-20 更新60
Microarray data of CTNS-/- vs Wildtype mouse kidney
Rab11 family interacting protein 4 (Rab11-FIP4) regulates endocytic trafficking. A possible role for Rab11-FIP4 in the regulation of lysosomal function has been proposed, but its precise function in t
DataCite Commons2024-09-16 更新150
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective
Stroke is a leading cause of death and disability. The pathophysiological mechanisms associated with stroke are very complex and not fully understood. Lysosomal function has a vital physiological func
DataCite Commons2024-02-15 更新70



