The MYC oncogene has been studied for decades, yet there is still intense debate over how this transcription factor controls gene expression. Here, we seek to answer these questions with an in vivo re

NIAID Data Ecosystem20

Glioma MYC gene signature

胶质瘤基因组学

MYC基因调控

There is little overlap on publicily avaiable gene signatures and it is unclear how relevant these are to glioma biology. MYC is a very dynamically regulated gene, and it's gene signature will vary wi

NIAID Data Ecosystem10

The WNT-dependent gating of MYC requires non-canonical functions of a distal CTCF binding site (RNA-Seq II)

WNT信号通路

MYC基因调控

Abnormal WNT signaling increases MYC expression in colon cancer cells in part via oncogenic super-enhancer-(OSE)-mediated gating of the active MYC to the nuclear pore in a poorly understood process. W

NIAID Data Ecosystem30

S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells [HG-U133B]. Homo sapiens

胰腺癌转移

转移相关基因表达

Pancreatic cancer is a devastating disease with both local invasion and distant metastasis. Identifying the genes expressed in liver metastases and signatures of metastatic progression would therefore

NIAID Data Ecosystem20

Myc influences metastatic heterogeneity in pancreatic cancer.

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