Development of peptide mimics of a protective epitope of Vibrio cholerae Ogawa O-antigen and investigation of the structural basis of peptide mimicry.

This epitope is a structural peptide mimic of the Ogawa O-antigen from Vibrio cholera O1. Phage display libraries were biopanned against mAbs S-20-4 and S-20-6, which are specific for the protective epitope of Ogawa LPS, using low pH elution or non-elution. This unique sequence bound bound S-20-4.