Enantioselective [3 + 2] Annulation of Enals with 2‑Aminoacrylates Catalyzed by N‑Heterocyclic Carbene
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资源简介：
A novel and convenient strategy for the enantioselective synthesis of γ-lactam derivatives via N-heterocyclic carbene catalyzed formal [3 + 2] annulation of enals with 2-aminoacrylates is disclosed. This activation mode provides a complementary approach to the synthesis of various γ-lactam derivatives in good yields with excellent diastereo- and enantioselectivities. In this process, two consecutive stereocenters are constructed, and a quaternary carbon center is also established.
创建时间：
2017-07-13
