Dynamic metabolic and molecular changes during seasonal shrinking in <em>Sorex araneus</em>

To meet the challenge of wintering in place many high-latitude small mammals reduce energy demands through hibernation. In contrast, short-lived Eurasian common shrews,Sorex araneus, remain active and shrink, including energy-intensive organs in winter, regrowing in spring in an evolved strategy called Dehnel’s phenomenon. How this size change is linked to metabolic and regulatory changes to sustain their high metabolism is unknown. We analyzed metabolic, proteomic, and gene expression profiles spanning the entirety of Dehnel’s seasonal cycle in wild shrews. We show regulatory changes to oxidative phosphorylation and increased fatty acid metabolism during autumn-to-winter shrinkage, as previously found in hibernating species. But in shrews we also found upregulated winter expression of genes involved in gluconeogenesis: the biosynthesis of glucose from non-carbohydrate substrates. Co-expression models revealed changes in size and metabolic gene expression interconnect via FOXO signaling..., , , # Dynamic metabolic and molecular changes during seasonal shrinking in *Sorex araneus* [https://doi.org/10.5061/dryad.pc866t1w3](https://doi.org/10.5061/dryad.pc866t1w3) Here we present the supplemental data for the analyses conducted in the above manuscript. File information is discussed within the manuscript and below. ## Change Log From the previous version, this data set now includes raw proteomic data, metabolomic data, full transcriptomic results, and a new WGCNA analyses that correlates network change to body size rather than liver size. Additionally, we have removed the code to reproduce these analyses, which can now be found on our GitHub to more accurately track changes https://github.com/wrthomas315/Dehnels_Seasonal_RNAseq2 . ## Description of the data and file structure Supplementary data consists of 10 tables described below. **Supplemental Data Information** **Supplemental Data 1** – Sample information including (IDs, body mass, season, organ masses) and sequenc...,