ihypoxia-20220119.rar

we developed an integrated resource for the expression dynamics of proteins and candidate genes in response to hypoxia (iHypoxia), and this database contains 1629 expression events of 1215 proteins identified by low-throughput experiments (LTEs) and 456,852 quantitative expression events of 39,483 proteins identified by high-throughput experiments (HTEs) from five mammals that exhibit a response to hypoxia. Various experimental details such as the hypoxic experimental conditions, expression patterns, and samples were carefully collected and integrated. Furthermore, ~10,000 candidate genes were also integrated from diverse species inhabiting low oxygen environment. In addition, we conducted an orthologous search and identified 432,298 computationally detected proteins that may respond to hypoxia among 48 animals.

本研究开发了一套针对低氧应答的蛋白质及候选基因表达动态特征的整合资源库（iHypoxia）。该数据库收录了来自5种低氧应答哺乳动物的两类表达数据：一类为经低通量实验（low-throughput experiments, LTEs）鉴定得到的1215种蛋白质对应的1629个表达事件；另一类为经高通量实验（high-throughput experiments, HTEs）鉴定得到的39483种蛋白质对应的456852个定量表达事件。研究团队精心收集并整合了各类实验细节，涵盖低氧实验条件、表达模式及实验样本等信息。此外，本资源库还整合了约10000个来自栖息于低氧环境的不同物种的候选基因。同时，本研究通过同源序列搜索，在48种动物中鉴定出432298个经计算预测的、可能参与低氧应答的蛋白质。