Palladium-Catalyzed Direct Oxidative C–H Activation/Annulation for Regioselective Construction of N‑Acylindoles
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A Pd(II)-catalyzed C(sp3)–H/C(sp2)–H coupling/annulation of anilides and α-dicarbonyl compounds for the synthesis of diverse N-acyl indoles is described. The reaction is achieved by cascade C–H activation, coupling, and intramolecular cyclization. This protocol provides a variety of indoles with high functional group tolerance and excellent regioselectivity. The utility of this protocol is demonstrated by transforming the synthesized compound into diversely functionalized analogues.
创建时间：
2020-04-08
