Effect of knockdown of S100A4 on gene expression in A549 cells

S100A4 is a tumor metastasis-promoting protein and drives lung cancer cell invasion and its elevation level is associated with lymphovascular invasion and the decreased overall survival among lung cancer patients. However, how it alters cancer cell metabolism and how metabolic changes affect the invasive and metastatc capacity are unknown. We used microarray to identify the critical molecules downstream of S100A4 signaling that alters mitochondrial metabolism and promotes lung cancer cell invasion and metastasis.