PDGFRA-T674I in complex with covalent ponatinib derivative 19
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PDGFRA-T674I in complex with covalent ponatinib derivative 19 Descriptor: 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-~{N}-[4-(propanoylamino)-3-(trifluoromethyl)phenyl]benzamide, Platelet-derived growth factor receptor alpha Authors: Teuber, A, Rauh, D, Mueller, M.P. Deposit date: 2024-10-04 Release date: 2025-02-12 Last modified: 2025-02-26 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Design, Synthesis, and SAR of Covalent KIT and PDGFRA Inhibitors─Exploring Their Potential in Targeting GIST. J.Med.Chem., 68, 2025
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2024-10-04
