Crystal structure of ULK2 in complex with SBI-0206965
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Crystal structure of ULK2 in complex with SBI-0206965 Descriptor: 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}oxy)-N-methylbenzene-1-carboximidic acid, Serine/threonine-protein kinase ULK2 Authors: Chaikuad, A, Ren, H, Bakas, N.A, Lambert, L.J, Cosford, N.D.P, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2020-04-01 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J.Med.Chem., 63, 2020
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2020-04-01
