The mechanistic target of rapamycin (mTOR) promotes neuronal aging, but it remains unclear whether these effects arise from mTOR activity within neurons, other brain cell types, or peripheral tissues.
NatB is an N-terminal acetyltransferase consisting of a catalytic Nat5 subunit and an auxiliary Mdm20 subunit. In yeast, NatB acetylates N-terminal methionines of proteins during de novo protein synth
The mammalian target of rapamycin (mTOR) is a central regulator of cell growth and proliferation in response to growth factor and nutrient signaling. Consequently, this kinase is implicated in metabo