Fructose promoted purine de novo synthesis to generate IMP and drive conversion of IMP to AMP to maintain the rapid depletion of ATP. Fructose increased the breakdown of preformed PNs and the
Metabolic dysregulation is one of the most common causes of pediatric neurodegenerative disorders. However, how the disruption of ubiquitous and essential metabolic pathways predominantly affect neura
Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of
The metabolomics analysis of leukemia stem cells with or without drug treatment was performed using an ion chromatography mass spectrometer or a QExactive HF-X hybrid quadrupole orbitrap high-resoluti