MOESM1 of Molecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanoma

Additional file 1. Associations and correlations of TIM-3 and LGALS9 methylation and mRNA expression with clinical-pathological parameters, molecular features and immune cell infiltrates in N = 470 melanoma patients from The Cancer Genome Atlas. Molecular data were obtained from The Cancer Genome Atlas [28]. P-values refer to Kruskal-Wallis (> two group comparisons), Wilcoxon Mann-Whitney U (2 group comparison) tests, and Spearman’s rank correlation (continuous variables), respectively.附加文件1。本研究分析了来自癌症基因组图谱（The Cancer Genome Atlas, TCGA）的470例黑色素瘤患者中，T细胞免疫球蛋白黏蛋白3（TIM-3）与半乳糖凝集素9（LGALS9）的甲基化水平、mRNA表达与临床病理参数、分子特征及免疫细胞浸润的关联及相关性。本研究的分子数据均来自癌症基因组图谱[28]。本研究的P值分别对应以下统计检验方法：克鲁斯卡尔-沃利斯检验（用于两组以上比较）、威尔科克森-曼-惠特尼U检验（用于两组比较）以及斯皮尔曼秩相关分析（用于连续变量）。