Neurotransmitter clearance in synaptic cleft

Neurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synaptic cell. The neurotransmitter is cleared by either re-uptake by the pre-synaptic neuron, diffusion in the perisynaptic area, uptake by astrocytes surrounding the synaptic cleft or enzymatic degradation of the neurotransmitter.<BR>This topic will be annotated in a future release.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=112311神经递质在突触间隙释放后，将与突触后细胞的特定受体相结合，而神经递质的过量将被清除，以防止突触后细胞的过度激活。神经递质的清除可通过突触前神经元的重摄取、突触周围区域的扩散、突触间隙周围星形胶质细胞的摄取或神经递质的酶促降解来实现。本主题将在未来的版本中进行标注。Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=112311