Biologic Treatment Outcomes in Refractory Bullous Pemphigoid: An Evidence Base Review

Bullous pemphigoid (BP) is an autoimmune disorder characterized by tense blisters, urticarial plaques and intense pruritis. Initial treatment typically involves the use of topical and oral steroids; however, non-steroidal agents and biologics can also be used in refractory cases. This systematic review examines the treatment outcomes in BP refractory to conventional therapies, treated with biologics.大疱性类天疱疮（Bullous pemphigoid, BP）是一种以紧张性水疱、荨麻疹样斑块及剧烈瘙痒为特征的自身免疫性疾病。其初始治疗通常采用外用及口服糖皮质激素；不过，对于难治性病例，也可使用非甾体类制剂与生物制剂。本系统综述旨在探讨经生物制剂治疗的、对常规治疗难治的BP患者的治疗结局。