The link between Parkinson's disease and breast and prostate cancers: A meta-analysis

<i>Purpose</i>: Clinical observations have shown an increased morbidity for breast cancer or prostate cancer in patients with Parkinson's disease (PD), however, other reports have noted contradictory results. This pooled analysis was utilized to test whether PD is associated with the risk of breast or prostate cancer. <i>Methods</i>: We searched PubMed, Embase and Cochrane library and conducted a meta-analysis to clarify the correlation of PD with breast and/or prostate cancer risk. We identified 16 eligible articles from which odds ratios with 95% confident intervals were assessed as main measures in the pooled estimation. Subgroup analyses and cumulative meta-analysis were also performed. <i>Results</i>: Our results showed no PD risk associated with breast or prostate cancer in the overall population, which was supported by the results of cumulative meta-analyses. The subgroup analyses suggested no significant risk of breast or prostate cancer in patients with PD within relevant subsets, i.e. gender, ethnicity, PD diagnosis time or study design. No evidence of publication bias was observed across the involved studies. <i>Conclusions</i>: This meta-analysis indicates a lack of association between PD and risk of breast or prostate cancer.目的：临床观察显示，帕金森病（Parkinson's disease, PD）患者的乳腺癌或前列腺癌发病率有所升高，但另有研究报告得出了相反的结论。本荟萃分析旨在探讨帕金森病是否与乳腺癌或前列腺癌的发病风险相关。 方法：我们检索了PubMed、Embase及Cochrane图书馆数据库，并开展荟萃分析以明确帕金森病与乳腺癌和/或前列腺癌发病风险的相关性。最终纳入16篇符合纳入标准的文献，以比值比及95%置信区间作为本次汇总估计的主要效应指标。同时还进行了亚组分析与累积荟萃分析。 结果：本研究结果显示，在总体人群中，帕金森病与乳腺癌或前列腺癌的发病风险并无关联，这一结论得到了累积荟萃分析结果的支持。亚组分析结果表明，在性别、种族、帕金森病确诊时间或研究设计等相关亚组中，帕金森病患者的乳腺癌或前列腺癌发病风险均无显著升高。纳入的各项研究未发现存在发表偏倚的证据。 结论：本荟萃分析表明，帕金森病与乳腺癌及前列腺癌的发病风险之间不存在相关性。