sGC activators and sGC stimulators in CKD

<b>Methods:</b> We conducted a head-to-head comparison using 5/6 nephrectomized rats on a high salt diet (5/6Nx+HSD) to evaluate the efficacy of the sGC stimulator BAY 41-8543 and the sGC activator BAY 60-2770 in CKD progression. BAY 41-8543 (1 mg/kg; twice daily) and BAY 60-2770 (1 mg/kg; once daily) were administered by gavage for 11 weeks.<b>方法：</b> 本研究采用高盐饮食喂养的5/6肾切除大鼠（5/6Nx+HSD）开展头对头对照实验，以评估可溶性鸟苷酸环化酶（soluble guanylyl cyclase, sGC）刺激剂BAY 41-8543与sGC激活剂BAY 60-2770对慢性肾脏病（chronic kidney disease, CKD）进展的干预疗效。实验中分别以灌胃方式给予BAY 41-8543（1 mg/kg；每日两次）与BAY 60-2770（1 mg/kg；每日一次），连续给药11周。