Identification of ESX-1-dependent transcriptional response of human macrophages to Mycobacterium tuberculosis infection. Identification of ESX-1-dependent transcriptional response of human macrophages to Mycobacterium tuberculosis infection

Human macrophage transcriptional response to Mtb infection diverges at late timepoints post-infection with wild-type Mtb, eliciting a more sustained immune response than RD1-deleted mutant Overall design: A total of 18 human macrophage samples (infected vs. uninfected; wild-type vs. RD1 mutant Mtb) were collected at 2 timepoints (2h and 48h) and total RNA extracted for sequencing.