The efficacy of nonpharmacologic intervention for orthostatic hypotension associated with aging

Objective: To determine the efficacy and safety of non-pharmacological interventions for orthostatic hypotension (OH) secondary to aging. Methods: A total of 150 orthostatic challenges were performed in 25 older people (60-92 years) to determine cardiovascular responses to bolus-water drinking, compression stockings, abdominal compression and physical counter-manoeuvres. Primary outcome was response rate, as assessed by proportion of participants whose systolic drop improved by ≥10 mmHg. Results: The response rate to bolus water drinking was 56% (95% confidence interval 36.7, 74.2), with standing systolic BP (SBP) increasing by 12 mmHg (95%CI 4, 20). Physical counter-manoeuvres were efficacious in 44% (95%CI 25.8, 63.3) but had little effect on standing SBP [+7.5 mmHg (95%CI -1, 16)]. Abdominal compression was efficacious in 52% (95%CI 32.9, 70.7) and improved standing SBP [+10 mmHg (95%CI 2, 8). Compression stockings were the least efficacious therapy, 32% (95%CI 16.1, 51.4) and had ...研究目的：旨在明确针对老年继发性体位性低血压（orthostatic hypotension, OH）的非药物干预手段的有效性与安全性。 研究方法：本研究纳入25名年龄介于60至92岁的老年人，共完成150次体位激发试验，以评估快速饮水、压力袜、腹部加压及物理对抗动作对心血管系统的影响。主要结局指标为应答率，即收缩压下降幅度改善≥10mmHg的受试者占比。 研究结果：快速饮水的应答率为56%（95%置信区间：36.7~74.2），站立位收缩压（systolic BP, SBP）升高12mmHg（95%置信区间：4~20）。物理对抗动作的应答率为44%（95%置信区间：25.8~63.3），但对站立位收缩压的提升效果有限[升高7.5mmHg（95%置信区间：-1~16）]。腹部加压的应答率为52%（95%置信区间：32.9~70.7），可提升站立位收缩压[升高10mmHg（95%置信区间：2~8）]。压力袜是本次研究中有效性最低的干预手段，应答率为32%（95%置信区间：16.1~51.4），且……