Stem cells utilize m6A-mediated decay via YTHDF2 to regulate neural differentiation and promote pluripotency
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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The m6A methylation pathway has previously been shown to influence pluripotency. YTHDF2 is an RNA binding protein that interacts with m6A-modified RNAs to facilitate their degradation. We sought to identify the cohort of RNAs targeted by YTHDF2 in human induced pluripotent stem cells (iPSC).
此前已有研究证实，m6A甲基化通路（m6A methylation pathway）可调控细胞多能性。YTHDF2是一种RNA结合蛋白（RNA binding protein），能够与携带m6A修饰的RNA结合并促进其降解。本研究旨在鉴定人诱导多能干细胞（induced pluripotent stem cells, iPSC）中YTHDF2所靶向的RNA靶标群体。
创建时间：
2022-02-20
