Linkage of <i>Eae23</i>.

Linkage of Eae23 in 428 (DA × PVG.1AV1)G10 AIL female rats. The significance thresholds are indicated in parenthesis and are the maximum LOD scores obtained from the analysis of residual values from family mean data for each phenotype. aPeak marker indicates the microsatellite marker closest to the highest LOD score obtained within the QTL. The fit multiple QTL model was used to validate the independent effects of Eae23a and Eae23b (phenotype = Eae23a + Eae23b + ε) and the locations used corresponds to the peak markers. A significant difference in the phenotypic variance defines an independent QTL, and is indicated by * = p<0.05 and ** = p<0.01. bA drop in LOD score of 1.5 from the maximum LOD (LOD support interval) was used to define the confidence intervals. Positions are given in Mb. cProbabilities were calculated from simulated pedigrees as the percentage of times the maximum LOD was located within the confidence interval of each QTL. Abbreviations: INC = incidence of EAE, ONS = onset of EAE, MAX = maximum EAE score, DUR = duration of EAE, CUM = cumulative EAE score, S.I = Support Interval.