Indicators of system performance in child TB case contact management.

aIndex cases interviewed at diagnosis to identify case, contact, and household factors associated with non-attendance. A study of 500 contacts is advised, assuming non-attendance of at least 20%.bCohort study of 500 enables evaluation of risk factors for non-adherence (taking cn = 2,000 is estimated to identify “secondary cases” on the basis of 60%–90% efficacy of preventive therapy, an assumption of >80% adherence and a natural progression off treatment of up to 20% over one year [2].dCohort of 200 is based on an expected incidence of symptomatic hepatotoxicity due to IPT of [25].