Genetically defined human GBM organoids reveal principles of GBM development and actionable targets

We used single cell RNA sequencing (scRNA-seq) to analysis the cellular state of organoids harboring different genetic mutations scRNA-sequencing data for 1- and 4-month-old WT (wildtype), PT (PTEN-/-; TP53-/-), PTCC (PTEN-/-; TP53-/-; CDKN2A-/-; CDKN2B-/-), and PTN (PTEN-/-; TP53-/-; NF1-/-) organoids samples