Serum antibody response to influenza viruses after one and two doses of intranasal vaccine.
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Groups of three ferrets were vaccinated intranasally with the indicated 1st dose of vaccine and 42 days later were inoculated with a 2nd dose of vaccine (H5N1 HK03 ca or VN04 ca). Serum samples were collected 6 weeks after the 1st dose (pre-dose 2), 1 week and 3 weeks after the 2nd dose, respectively, and antibody titers (geometric mean titers from 3 animals) against the first or second vaccine viruses were determined by microneutralization assay.
创建时间：
2013-02-21
