BATF orchestrates the functional specification and metabolic reprogramming in Treg cells. BATF orchestrates the functional specification and metabolic reprogramming in Treg cells

Purpose: Identification of the differentially expressed genes and metabolic pathways in resting and activated WT and BATF-deficient Treg cells Methods: RNA was purified from resting of stimulated (aCD3-CD38/IL-2 for 48 h)Treg cells isolated from WT or Foxp3CreBatffl/fl mice Results: Loss of BATF promotes triacylglycerol biosynthesis in Treg cells. Conclusions: BATF is crucial to coordinate the suppressive function and triacylglycerol metabolism of Treg cells. Overall design: In total 12 samples were analyzed: WT (3 Unstimulated and 3 Stimulated); Batf Ko (3 Unstimulated and 3 stimulated)