Transcriptome profiling of WM3248 melanoma cells following PGC1-alpha knockdown

PGC1-alpha is a transcriptional coactivator that controls diverse cellular processes, including metabolism. PGC1-alpha expression is increased in invasive primary melanoma. To understand the role of PGC1-alpha in the invasive growth of primary melanoma, we generated transcriptional (RNA-Seq) profiles of WM3248 primary melanoma cells that were transfected with either negative control or PGC1-alpha siRNA. Cells were transfected with validated siRNAs: AllStars (negative control) or PGC1-alpha. RNA was harvested 48h later and used for RNA-Seq.